Bariatric Surgery and Gut Microbiota Changes Over Time

Starting soon

Conditions studied: Obese Patients, Obese Patients With Bariatric Surgery, Gut Microbiota, Healthy Participants

In brief

The goal of this observational study is to learn how bariatric surgery affects gut bacteria and gut-related metabolic products over time in adults with obesity. The study includes adults aged 18 to 65 years who are undergoing Roux-en-Y gastric bypass (RYGB) surgery, as well as adults with obesity treated with diet alone and healthy normal-weight adults. The main questions it aims to answer are: How does bariatric surgery change the composition and diversity of gut bacteria over time? How are these changes related to weight loss and improvement of obesity-related health conditions? Researchers will compare people undergoing bariatric surgery with people with obesity treated with diet alone and with healthy normal-weight individuals to see if surgery leads to specific changes in gut bacteria and stool metabolites that are linked to better clinical outcomes. Participants will: Provide stool samples at scheduled time points over 12 months Provide blood samples and undergo routine clinical assessments Take part in follow-up visits to monitor weight, metabolic health, and gastrointestinal symptoms

Key facts

Study ID
NCT07381140
Run by
Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis
People needed
100
Starts
2026-04-01
Expected to finish
2028-04-01
Last updated by the study team
2026-02-05

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.

Where it is running

Full record on ClinicalTrials.gov

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