geniculaR Artery eMBolization for Knee Osteoarthritis (RAMBO) Registry

Recruiting now

Conditions studied: Knee Osteoarthristis

In brief

The goal of this observational study (prospective registry) is to collect long-term real-world data on the effectiveness and safety of genicular artery embolization (GAE) for knee osteoarthritis in adults aged 18 years or older with symptomatic KOA that has not responded to medical therapy. The main questions it aims to answer are: 1. Does GAE lead to sustained improvement in pain (WOMAC, VAS) and quality-of-life scores over 12-36 months? 2. What patient or procedural factors are associated with better outcomes after GAE? Participants will: * Undergo GAE as part of their routine clinical care. * Complete clinical follow-up assessments at 1, 3, 6, 12, 18, 24, and 36 months after treatment, including symptom and quality-of-life questionnaires. * Have safety outcomes tracked according to Society of Interventional Radiology guidelines. There is no comparison group; results will be analyzed to identify predictors of success and inform best practices for patient selection and treatment.

Key facts

Study ID

NCT07380906

Run by

Joint & Vascular Institute

People needed

1200

Starts

2025-07-16

Expected to finish

2030-07-01

Last updated by the study team

2026-06-12

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adults (≥18 years) with symptomatic KOA refractory to medical therapy, referred for GAE.

You may not qualify if…

• Pregnancy, coagulopathy, severe comorbidities, or inability to consent.

Where it is running

• Joint and Vascular Institute — Libertyville, Illinois, United States (enrolling)

Full record on ClinicalTrials.gov

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