VentricuLostomy AssoCiaTed InfeCtions (LACTIC): Focus on CSF Lactate and Sampling Site
Recruiting now
Conditions studied: Acute Brain Injury, Hydrocephalus, External Ventricular Drain, External Ventricular Drainage Associated Infection
In brief
This observational study involving patients with acute brain injury undergoing treatment with an external ventricular drain consists of three subprojects, aiming to: 1. investigate various biomarkers, with a primary focus on the development of cerebrospinal fluid lactate in relation to ventriculostomy-associated infection; 2. compare proximal and distal sample results obtained from an external ventricular drain; 3. describe the natural progression of various biomarkers in blood and cerebrospinal fluid following acute brain injury.
Key facts
- Study ID
- NCT07380477
- Run by
- Rigshospitalet, Denmark
- People needed
- 148
- Starts
- 2025-01-15
- Expected to finish
- 2029-10-01
- Last updated by the study team
- 2026-02-02
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age >18 years
- EVD in situ
- Admission to the neuro-ICU or neurosurgical step-down unit at Rigshospitalet, Denmark
- Diagnosis of acute brain injury categorized as traumatic brain injury, subarachnoid haemorrhage, intracranial haemorrage, intraventricular haemorrhage
You may not qualify if…
- Patient or closest relatives do not understand written and spoken Danish or English
- Patients transferred to Rigshospitalet with an EVD
- Patients with brain injury due to existing brain infection (e.g., meningitis, intracranial empyema or abscess, encephalitis)
- Patients with existing ventriculoperitoneal or ventriculoatrial shunt at the time of admission
- Patients with primary or secondary brain cancer
- Patients died or in palliative care
Where it is running
- Rigshospitalet — Copenhagen, Denmark (enrolling)
Full record on ClinicalTrials.gov
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