A Clinical Trial of PepZinGI® for Acute Heartburn Relief and Sleep Outcomes

Completed · Not applicable · Has a placebo group

Conditions studied: Heartburn

In brief

This decentralized, randomized, double-blind, placebo-controlled, two-period crossover study will evaluate whether PepZinGI® (zinc-L-carnosine) reduces food-triggered heartburn compared with placebo. Participants (N=50) complete two 1-week treatment periods (PepZinGI® and placebo) separated by a 2-week washout, for a total of 29 days. Primary outcomes are heartburn severity and frequency measured by the NutriScience Heartburn Questionnaire; secondary outcomes include PROMIS GI Reflux-13a, time to relief, rescue medication use, wearable-derived sleep metrics, Karolinska Sleep Scale, sleep diary entries, and satisfaction. All activities are remote through Alethios; no in-person visits.

Key facts

Study ID

NCT07379645

Run by

NutriScience Innovations, LLC

People needed

50

Starts

2026-01-15

Expected to finish

2026-05-11

Last updated by the study team

2026-06-17

Who can join

Age: 21 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age ≥21 years
• Self-reported food-triggered heartburn with known trigger foods
• Heartburn at least once per week
• Willing to avoid OTC/supplement heartburn treatments during study (calcium-carbonate rescue allowed but must be logged and not used during hurdle-meal day/night)
• Able to complete electronic surveys and adhere to procedures
• Access to or willingness to use a compatible wearable device

You may not qualify if…

• Clinician-diagnosed GERD, UC, Crohn's, or IBD
• Prescribed drugs for heartburn/digestive conditions
• Heartburn less than once per week or daily throughout the month
• More than 1 alcoholic drink/day on average during study
• Recreational drug use during study
• Known allergy to zinc, L-carnosine, or study ingredients
• Pregnant or breastfeeding

Where it is running

• Alethios, Inc — San Francisco, California, United States

Full record on ClinicalTrials.gov

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