Lung Recruitment Assessed by 2D/3D-EIT and R/I Ratio in Acute Respiratory Failure Patients With Mechanical Ventilation
Recruiting now
Conditions studied: Acute Respiratory Failure (ARF)
In brief
The purpose of this observational study is to assess the differences and consistency in evaluating lung recruitment potential between the recruitment-to-inflation ratio (R/I ratio) and three-dimensional electrical impedance tomography (3D-EIT) and two-dimensional EIT (2D-EIT) in mechanically ventilated patients with acute respiratory failure. The main questions it aims to answer is: Are the lung recruitment potentials predicted by 3D-EIT, 2D-EIT and the R/I ratio consistent? Participants will: Undergo a standardized PEEP titration protocol with synchronized EIT monitoring; Have R/I ratios measured at high and low PEEP levels.
Key facts
- Study ID
- NCT07379242
- Run by
- Peking Union Medical College Hospital
- People needed
- 50
- Starts
- 2025-09-01
- Expected to finish
- 2026-09-30
- Last updated by the study team
- 2026-01-30
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Mechanically ventilated patients under sedation and analgesia with no spontaneous breathing.
- Oxygenation index < 300 mmHg.
- Patients who are clinically judged by the attending doctor to require the PEEP titration.
You may not qualify if…
- Aged under 18 years.
- Pregnancy.
- Contraindications for EIT examination (e.g. automatic implantable cardioverter defibrillator, implantable pumps, chest wounds limiting electrode belt placement, severe thoracic deformity, and others).
- No informed consent obtained.
- Hemodynamic instability with intolerance to high PEEP levels determined by the attending doctor.
- High-risk populations with pneumothorax, mediastinal emphysema, and other such conditions determined by the attending doctor.
Where it is running
- Department of Critical Care Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences — Beijing, Beijing Municipality, China (enrolling)
Full record on ClinicalTrials.gov
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