Effects of Selected Statins on Blood Glucose Levels in Healthy Volunteers

Starting soon · Phase 1

Conditions studied: Diabete Mellitus, Lipid Profile

In brief

This Phase I randomized clinical trial aims to investigate the short-term effects of three commonly prescribed statins (atorvastatin, rosuvastatin, and simvastatin) at different dose levels on blood glucose homeostasis in healthy volunteers. The study will assess changes in fasting blood glucose, insulin, and C-peptide levels following two days of statin administration under controlled conditions. The research seeks to provide comparative data on the potential diabetogenic effects of these medications.

Key facts

Study ID

NCT07378293

Run by

Shaheed Benazir Bhutto University Sheringal Dir Upper

People needed

100

Starts

2026-03-01

Expected to finish

2027-02-20

Last updated by the study team

2026-01-30

Who can join

Age: 18 and older, up to 55. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• healthy volunteers
• Non diabetic
• blood glucose level (less than140 mg/dl)

You may not qualify if…

• Participants with a history of diabetes mellitus
• With chronic diseases e.g heart disease, kidney disease
• participants taking other medications

Where it is running

• Shaheed Benazir Bhutto University Sheringal Dir Upper — Dīr, Khyber Pakhtunkhwa, Pakistan
• Shaheed Benazir Bhutto University Sheringal Dir Upper — Dīr, Khyber Pakhtunkhwa, Pakistan

Full record on ClinicalTrials.gov

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