Effect of Patient Position on Bupivacaine Dose Requirement and Hemodynamic Stability in Spinal Anesthesia
Starting soon · Not applicable
Conditions studied: Spinal Anesthesia, Hemodynamic Changes, Patient Positions, Bupivacaine
In brief
This study compares different combinations of local anesthetic doses and patient positions during spinal anesthesia for urogenital surgery. Spinal anesthesia is a common and safe technique where medication is injected into the lower back to numb the body during surgery. The study will test two different doses of bupivacaine (a numbing medication): a lower dose (8 mg) and a standard dose (12 mg). It will also test two different patient positions after the spinal injection: lying flat (neutral position) and lying with the head slightly lower than the feet (Trendelenburg position). Participants will be randomly assigned to one of four groups: * Group 1: Lower dose + lying flat * Group 2: Lower dose + head-down position * Group 3: Standard dose + lying flat * Group 4: Standard dose + head-down position The study will measure how well the anesthesia works, how high the numbness spreads in the body, and how it affects blood pressure and heart rate. The goal is to find the best combination of dose and position that provides good anesthesia while keeping blood pressure stable. This research may help doctors choose the safest and most effective anesthesia approach for each patient based on their individual needs.
Key facts
- Study ID
- NCT07376798
- Run by
- University of Health Sciences Balikesir Hospital Eduation and Research
- People needed
- 100
- Starts
- 2026-01-30
- Expected to finish
- 2026-06-30
- Last updated by the study team
- 2026-01-29
Who can join
Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age 18-70 years
- American Society of Anesthesiologists (ASA) physical status classification I-II
- Scheduled for elective urogenital surgery
- Suitable candidate for spinal anesthesia
- Able to read, understand, and provide written informed consent
- Body Mass Index (BMI) less than 35 kg/m²
- Willing to participate in the study
You may not qualify if…
- Contraindications to spinal anesthesia (coagulopathy, infection at injection site, patient refusal)
- History of neurological disease
- Spinal deformity or previous spinal surgery
- History of allergic reaction to local anesthetics (amide-type)
- ASA physical status classification III or higher
- Emergency surgery
- Pregnancy
- Psychiatric illness preventing effective communication
- Refusal to participate in the study
- Unable to understand or provide informed consent
Full record on ClinicalTrials.gov
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