Assessing the Impact of High Theacrine Doses on Hemodynamic Measures

Completed · Not applicable · Has a placebo group

Conditions studied: Hemodynamic Measure, Cognitive Performance in Healthy Volunteers

In brief

This project measured physiological and cognitive variables to determine the effectiveness of Theacrine (TCR) as a stimulant at doses greater than those previously tested. The study will be the first TCR study to use doses relative to body weight and will investigate impacts on regular caffeine consumers. A secondary aim of the study is to determine the impact of acute TCR supplementation on salivary cortisol and sAA, two physiological measures of stress and sympathetic nervous system activation. The findings of the study will provide new insight into the effects of higher TCR dosages, contributing to the analysis of TCR as a caffeine alternative for individuals with hypertension, tachycardia, or healthy caffeine consumers wanting to avoid a stimulant with adverse or habitual effects

Key facts

Study ID

NCT07376564

Run by

Titch Madzima

People needed

19

Starts

2023-08-09

Expected to finish

2024-11-01

Last updated by the study team

2026-01-29

Who can join

Age: 18 and older, up to 40. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• habitual caffeine consumer (≥2 days/week)

You may not qualify if…

• existing heart disease or conditions (cardiovascular and/or heart disease, stroke, diabetes hypertension, tachycardia)
• a smoker
• allergy to caffeine or Theacrine
• caffeine sensitivity (negative symptoms such as jitters after consuming low doses)
• pregnant
• on heart or blood pressure medication

Where it is running

• Department of Exercise Science, Koury Athletics Center at Elon University — Elon, North Carolina, United States

Full record on ClinicalTrials.gov

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