Effects of Whole Fruit on Blood Sugar in People With Type 2 Diabetes

Starting soon · Not applicable

Conditions studied: Type 2 Diabetes

In brief

This study will determine the effects of consuming whole fruit on blood sugar control, liver fat, and cardiovascular health in adults with type 2 diabetes who are not treated with insulin.

Key facts

Study ID

NCT07376226

Run by

Harvard School of Public Health (HSPH)

People needed

25

Starts

2026-09-01

Expected to finish

2028-04-01

Last updated by the study team

2026-07-07

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Aged ≥18 years
• Diagnosed with type 2 diabetes
• HbA1c between 6.5-12.0%
• Fasting C-peptide level ≥0.5 ng/ml, indicating the patient does not have beta-cell failure, as measured at screening

You may not qualify if…

• On insulin
• Evidence of latent autoimmune diabetes (LADA) or maturity-onset diabetes of the young (MODY)
• Estimated glomerular filtration rate (eGFR) <45 ml/min per 1.73 m²
• Heart attack in the past 6 months or severe/unstable heart failure
• On weight loss medication, including GLP-1 receptor agonists (e.g., semaglutide, dulaglutide)
• Change in the dosage of a chronic medication that may affect study endpoints within the past 3 months
• Clinically significant laboratory abnormality (e.g., abnormal hemoglobin levels)
• Significant gastrointestinal disease, major gastrointestinal surgery, or gallstones
• Significant cardiovascular, renal, cardiac, liver, lung, adrenal, or nervous system disease that might compromise participant safety or data validity
• Evidence of cancer (other than non-melanoma skin cancer) within the last 5 years
• Lost or gained more than 5 lbs (or more than 2% of body weight if the patient weighs >250 lbs) of weight in the past 2 months
• Pregnant, planning to become pregnant in the next 6 months, or breastfeeding
• Major psychiatric condition that would affect the ability to participate in the study
• Not able to eat the provided study meals (e.g., food allergies)
• Behavioral factors or circumstances that may impede adherence to the dietary intervention
• Not able to undergo the MRI scan (e.g., due to claustrophobia, implanted metal objects, or body girth ≥60 cm)

Where it is running

• Harvard T. H. Chan School of Public Health — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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