Transcranial Electrical Stimulation for Noninvasive Study of Menopausal/Perimenopausal Symptoms

Starting soon · Not applicable

Conditions studied: Menopausal Depression, Menopause Hot Flashes, Menopause, Menopause Related Conditions

In brief

Participants are being invited to a research study. This research aims to assess the tolerability of transcranial electrical stimulation of the brain, and explore the response of TES on menopausal/perimenopausal symptoms including hot flashes effects, depression/anxiety, memory-problems, and muscular problems. This study will assess what types of electrical brain stimulation affect different menopausal related symptoms. This study will help guide the development of electrical stimulation to be used for improving women's health during menopause transition.

Key facts

Study ID

NCT07375732

Run by

Carnegie Mellon University

People needed

50

Starts

2026-02-01

Expected to finish

2027-04-01

Last updated by the study team

2026-01-29

Who can join

Age: 40 and older, up to 60. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Age between 40 and 60 years
• Participants falling under stages -2 to +2 in the Stages of Reproductive Aging Workshop (STRAW +10) as defined below:
• Early menopause transition (Stage -2): Increased variability in menstrual cycle defined as persistent difference of 7 days or more in the length of consecutive cycles. Persistence is defined as recurrence within 10 cycles of the first variable cycle.
• Late menopause transition (Stage -1): Occurrence of amenorrhea of 60 days or longer.
• Final Menstrual Period (Stage 0): Have undergone 12 consecutive months without a menstrual period, not due to other medical causes.
• Early Postmenopause (Stage +1): 5-8 years after final menstrual period.
• Late Postmenopause (Stage +2): >8 years after final menstrual period.
• Participants having frequent hot flashes (at least once a day).

You may not qualify if…

• Disorders that may mask or coincide with menopause and peri-menopause, such as: Primary Ovarian Insufficiency, Thyroid disease (Hyper/hypothyroidism), Hyperprolactinemia, Cushing's syndrome, Endometrial/Ovarian Cancer, Polycystic Ovary Syndrome (PCOS), Functional hypothalamic amenorrhea
• Concurrent drugs:
• GnRH agonist/antagonist
• Tamoxifen/aromatase inhibitors
• Other conditions: Recent hematoma (<48 hours), History of hemorrhagic disorders (any platelet disorder (ITP, TTP, HUS, Glanzmann thrombasthenia), Hemophilia A/B, history of arterial insufficiency, any prior history of malignancy, current pregnancy, a lifetime history of severe, uncontrolled mood disorders (anxiety, depression, bipolar), psychotic disorders, other neural disorders, or heart disease, any condition that makes them unable to perform tasks outlined in experiment, tattoos on sensory testing sites.

Full record on ClinicalTrials.gov

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