Effect of Melatonin on Oxidative Stress Parameters in Levodopa-Treated Parkinson's Disease Patients
Enrolling by invitation · Phase 2 · Has a placebo group
Conditions studied: Parkinson Disease
In brief
In Bangladesh Melatonin is currently used for insomnia. Its potential therapeutic benefits beyond sleep regulation. This study aimss to evaluate the effects of melatonin supplementation on oxidative stress markers, neuroinflammation and clinical outcomes in patients with Parkinson's disease. The main question it aims to answer: In patients with Parkinson's disease receiving levodopa, does melatonin supplementation, compared to levodopa treatment alone, improve the symptoms of PD over a 12 week of period. Participants will: Take Melatonin 10mg or placebo everyday for 3 months at night 30minutes before bedtime. Visit the clinic once every 6 weeks for checkups and tests keep a diary of their symptoms,UPDRS score. At the end of 12 weeks will reaper hs-CRP, MDA and GSH.
Key facts
- Study ID
- NCT07375693
- Run by
- Bangladesh Medical University
- People needed
- 70
- Starts
- 2026-02-17
- Expected to finish
- 2026-09-15
- Last updated by the study team
- 2026-01-29
Who can join
Age: 45 and older, up to 85. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- diagnosesd Parkinson's disease patients taking levodopa
- mild to moderate PD pt according to Hohen and Yahr staging, stage-I,II,III
- age:>45 years
- both male and female
You may not qualify if…
- secondary causes of PD
- Prior stereotactic surgery for PD
- suffering from active malignancy
- known hypersensitivity to melatonin
- Patients taking anticonvulsants, OCP, DMARD
- pt with autoimmune disease
- pregnancy or lactating mother
- has any clinically significant medical condition that could interfere with the subject's ability to safely participate in the study or to be followed
Where it is running
- Bangladesh medical university — Dhaka, Dhaka Division, Bangladesh
Full record on ClinicalTrials.gov
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