Effect of Esketamine on Perioperative Negative Emotions in Breast Cancer Surgery Patients With Severe Depression

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Conditions studied: Depression, Anxiety, S-ketamine, Breast Cancer

In brief

This project employs a prospective, randomized, controlled, blinded, dual-center study design to investigate the effects of intraoperative esketamine on perioperative anxiety and depression symptoms in patients with severe depression undergoing breast cancer surgery.

Key facts

Study ID

NCT07374211

Run by

Chinese PLA General Hospital

People needed

242

Starts

2026-01-18

Expected to finish

2027-02-01

Last updated by the study team

2026-01-28

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥ 18 years.
• Scheduled to undergo elective breast cancer resection surgery.
• American Society of Anesthesiologists (ASA) physical status classification of I-III.
• Clearly understand and voluntarily agree to participate in the study, and sign the informed consent form.
• Female patients with severe depressive symptoms (defined as a Hospital Anxiety and Depression Scale-Depression subscale score of ≥15)
• Anticipated anesthesia duration greater than 90 minutes.

You may not qualify if…

• Patients with significant preoperative abnormalities in cardiac, pulmonary, hepatic, or renal function, or coagulation disorders .
• Patients taking antipsychotics, antidepressants, or glucocorticoids, or with a history of alcohol abuse or illicit drug use .
• Patients with an MMSE score <18, dementia, intellectual disability, or those unable to communicate (e.g., coma, severe dementia, hearing or language impairment) .
• Patients with a history of psychiatric or neurological disorders (e.g., schizophrenia, epilepsy, Parkinson's disease, or severe myasthenia gravis) .
• Patients with poorly controlled or untreated hypertension (≥180/110 mmHg) .
• Patients with elevated intracranial or intraocular pressure.
• Patients with untreated or inadequately treated hyperthyroidism .
• Patients with a known allergy to the drugs involved in this study .
• Patients unable to complete the assessment scales required by this study.
• Patients who are currently participating in other clinical trials

Full record on ClinicalTrials.gov

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