Effect of Continuous Intraoperative Esketamine Infusion on Perioperative Negative Emotions in Breast Cancer Surgery Patients With Mild-to-Severe Depression
Starting soon · Not applicable
Conditions studied: Depression, Anxiety, S-ketamine, Breast Cancer
In brief
A Dual-Center, Randomized, Controlled, Blinded, Prospective Study on the Effects of Esketamine on Perioperative Negative Emotions in Breast Cancer Surgery Patients with Mild-to-Severe Depression
Key facts
- Study ID
- NCT07374198
- Run by
- Chinese PLA General Hospital
- People needed
- 142
- Starts
- 2026-01-18
- Expected to finish
- 2027-02-01
- Last updated by the study team
- 2026-01-28
Who can join
Age: 18 and older. Sex: female. Healthy volunteers: not accepted.
You may qualify if…
- Age ≥ 18 years.
- Scheduled to undergo elective breast cancer resection surgery.
- American Society of Anesthesiologists (ASA) physical status classification of I-III.
- Clearly understand and voluntarily agree to participate in the study, and sign the informed consent form.
- Female patients with mild to severe depressive symptoms (defined as a Hospital Anxiety and Depression Scale-Depression subscale score of ≥8)
- Anticipated anesthesia duration greater than 90 minutes.
You may not qualify if…
- Patients with significant preoperative abnormalities in cardiac, pulmonary, hepatic, or renal function, or coagulation disorders .
- Patients taking antipsychotics, antidepressants, or glucocorticoids, or with a history of alcohol abuse or illicit drug use .
- Patients with an MMSE score <18, dementia, intellectual disability, or those unable to communicate (e.g., coma, severe dementia, hearing or language impairment) .
- Patients with a history of psychiatric or neurological disorders (e.g., schizophrenia, epilepsy, Parkinson's disease, or severe myasthenia gravis) .
- Patients with poorly controlled or untreated hypertension (≥180/110 mmHg) .
- Patients with elevated intracranial or intraocular pressure.
- Patients with untreated or inadequately treated hyperthyroidism .
- Patients with a known allergy to the drugs involved in this study .
- Patients unable to complete the assessment scales required by this study.
- Patients who are currently participating in other clinical trials
Full record on ClinicalTrials.gov
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