HOXB7 and Linked Tissue and Blood Biomarkers in the Lungs of Patients With Pulmonary Fibrosis

Recruiting now

Conditions studied: Fibrosis, Pulmonary

In brief

This pilot, multicenter, interventional study investigates the expression of HOXB7 and its associated molecular pathway in lung tissue and blood-derived exosomes from patients with pulmonary fibrosis (PF), including idiopathic pulmonary fibrosis (IPF). Using RNA sequencing (RNA-Seq) and proteomic analysis via mass spectrometry (MS), the study aims to identify tissue and circulating biomarkers associated with fibrosis progression. The study compares different biopsy techniques (surgical vs. transbronchial cryobiopsy) and also includes a control group of patients undergoing lung resection for non-fibrotic conditions.

Key facts

Study ID

NCT07373288

Run by

University of Modena and Reggio Emilia

People needed

80

Starts

2023-07-01

Expected to finish

2030-07-01

Last updated by the study team

2026-02-04

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adults aged 18 to 80 with clinical suspicion of pulmonary fibrosis
• Availability of fresh lung tissue from biopsy or lung explant
• Signed informed consent for research use of biological material and data

You may not qualify if…

• Refusal to sign informed consent

Where it is running

• Azienda Ospedaliero Universitaria Policlinico di Modena — Modena, Italy (enrolling)

Full record on ClinicalTrials.gov

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