Open-label Placebo for Pain Management in Adolescents and Young Adults Undergoing Bernese Periacetabular Osteotomy

Recruiting now · Not applicable · Has a placebo group

Conditions studied: Periacetabular Osteotomy, Opiates

In brief

In this randomized controlled trial, 64 participants undergoing PAO at UCSF will be enrolled and randomized to receive either COLP plus treatment as usual (TAU) or TAU alone. Patients in the COLP arm will receive placebo pills alongside prescribed opioids and at scheduled intervals, beginning on postoperative day one. Weekly follow-up will be conducted for six weeks postoperatively via remote surveys and video visits.

Key facts

Study ID

NCT07373210

Run by

University of California, San Francisco

People needed

64

Starts

2026-12-01

Expected to finish

2028-03-31

Last updated by the study team

2026-04-29

Who can join

Age: 13 and older, up to 40. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Aged 13 to 40 years old, and
• Undergo primary Bernese Periacetabular osteotomy (PAO) for symptomatic developmental dysplasia of the hip (DDH), and
• Opioid-naïve prior to operation, and
• Capable of completing study procedures, including daily pain and medication diaries as well as weekly questionnaires.

You may not qualify if…

• Undergoing PAO revision or any concurrent major surgical procedure
• History of opioid use, substance use disorders, or alcohol abuse
• Those with cognitive or physical impairments that would interfere with providing their own consent and the completion of study-related tasks
• Pregnant individuals or those planning to become pregnant during the study period

Where it is running

• University of California San Francisco — San Francisco, California, United States (enrolling)

Full record on ClinicalTrials.gov

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