Cerclage Plus Progesterone vs Progesterone Alone in Twin Short Cervix

Recruiting now · Not applicable

Conditions studied: Preterm

In brief

This study aims to compare the effectiveness of cervical cerclage combined with progesterone versus progesterone alone in preventing preterm birth among women with twin pregnancies and a short cervix (cervical length ≤ 30 mm). Participants will be randomly allocated to either the intervention group (cerclage plus progesterone) or the control group (progesterone alone).

Key facts

Study ID

NCT07372495

Run by

National Hospital of Obstetrics and Gynecology

People needed

260

Starts

2026-04-10

Expected to finish

2029-05-30

Last updated by the study team

2026-04-24

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Maternal age ≥ 18
• Twin pregnancy
• Asymptomatic short cervix (CL≤30mm) at routine ultrasound investigation
• Gestational age at 16+0- 24+0 weeks

You may not qualify if…

• A potential paticipant who meets any of the following criteria will be excluded from participation in this trial:
• Women with twin pregnancy in which one or both fetuses are diagnosed with a major structural or congenital abnormality that is likely to influence the composite adverse neonatal outcome.
• Women with a monochorionic monoamniotic twin pregnancy
• A monochorionic twin pregnancy with twin-to-twin transfusion syndrome before or at the time of inclusion.
• Patients have indications for vaginal cerclage: Recurrent late miscarriage (from 14 weeks) or preterm birth occurring two or more times.
• Women with dilatation of the cervix diagnosed by ultrasound or physical exam
• Women with overt symptoms of preterm labor at the time of measurement of the short cervix (regular contractions, PPROM, recurrent blood loss).
• Women with the presence of fever ≥ 38 degrees Celsius.
• Women with a placenta previa, vasa previa.
• Uterine malformations: unicornuate uterus, bicornuate uterus, uterine septum, fibroid…
• Severe maternal conditions (heart failure, chronic kidney disease, systemic lupus erythematosus …)

Where it is running

• National Hospital of Obstetrics and Gynecology — Hanoi, Vietnam (enrolling)
• Bac Ninh 1 Obstetrics and Pediatrics Hospital, Bac Ninh, Vietnam — Bac Ninh, Vietnam
• Bac Ninh 2 Obstetrics and Pediatrics Hospital, Bac Ninh, Vietnam — Bac Ninh, Vietnam
• Hung Yen Obstetrics and Pediatrics Hospital, Hung Yen, Vietnam — Hung Yen, Vietnam
• Ninh Binh Obstetrics and Pediatrics Hospital, Ninh Binh, Vietnam — Ninh Binh, Vietnam
• Quang Ninh Obstetrics and Pediatrics Hospital, Quang Ninh, Vietnam — Quang Ninh, Vietnam

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.