Wound Healing Following Extraction and Ridge Preservation in Smokers and Non-smokers
Starting soon
Conditions studied: Smoking, Cigarette, Alveolar Bone Grafting, Wound Healing, Bone Healing, Tooth Extraction Site Healing
In brief
The goal of this study is to evaluate bone wound healing following extraction and alveolar ridge preservation (bone graft and membrane) clinically, histologically and in relation to gene expression in smokers and non-smokers. Data from a small group of participants will be analyzed after age-matched subjects undergo extraction and alveolar ridge preservation prior to implant placement. The data obtained in this pilot study will be used to plan a full-fledged study involving a larger number of smoking and non-smoking participants to compare the two groups.
Key facts
- Study ID
- NCT07372183
- Run by
- Marquette University
- People needed
- 12
- Starts
- 2026-01-25
- Expected to finish
- 2028-10-01
- Last updated by the study team
- 2026-01-28
Who can join
Age: 18 and older, up to 75. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Adult patients (18-75 years)
- Good general health (controlled conditions)
- Smokers (≥10 cigarettes/day for ≥5 years) and never smokers. Confirmation of smoking status will be done via use of a smokerlyzer. The cut-off point for distinguishing smokers from non-smokers is 8 carbon monoxide parts per million (ppm).
- Periodontal status: periodontal health, gingivitis on intact or reduced periodontium, treated periodontitis
- Intact post-extraction bony walls or less than 50% bone dehiscence
- Distance at least 8 mm of vertical bone height between bone crest and anatomical structures (i.e. sinus floor, inferior alveolar nerve (IAN) canal, mental foramen)
- Extracted tooth root in the same three-dimensional position as the future implant placement so that the bone core biopsy can be taken from a site totally within the confines of the former tooth socket without inclusion of surrounding native alveolar bone
- Scheduled for single tooth extraction with bone graft placement and membrane
You may not qualify if…
- Uncontrolled periodontal disease
- Uncontrolled systemic disease
- Pregnancy
- Use of therapy and/or medication that impairs wound healing (e.g., bisphosphonates, steroids, chemotherapy, radiotherapy etc.)
Where it is running
- Marquette University School of Dentistry Graduate Periodontics Clinic — Milwaukee, Wisconsin, United States
Full record on ClinicalTrials.gov
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