Effect of Aprepitant on Post-operative Nausea and Vomiting in Otologic Surgery

Starting soon · Phase 4 · Has a placebo group

Conditions studied: Otologic Disease

In brief

This project is being carried out to study the use of a medication to reduce nausea and vomiting after ear surgery.

Key facts

Study ID

NCT07371728

Run by

Sir Mortimer B. Davis - Jewish General Hospital

People needed

100

Starts

2026-06-01

Expected to finish

2028-06-01

Last updated by the study team

2026-01-28

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult patients undergoing middle ear surgery including tympanoplasty with or without ossicular chain reconstruction, tympanomastoidectomy or stapedectomy
• Patient using a hormonal contraceptive will be included, but warned aprepitant may reduce the efficacy of hormonal contraception thus an alternative or backup contraceptive methods should be used for one month after surgery

You may not qualify if…

• Children (<18 years old)
• Patients unable to complete the post-procedure questionnaire (either due to time constraints, neurocognitive impairment, etc.)
• Patients taking concomitant medications that are substrates, inhibitors or inducers of CYP3A4 or CYP2CP that are at risk of having a clinically significant effect
• Patients with a history of hypersensitivity reaction to any of the medications used in the study
• Patients who are pregnant or breastfeeding
• Patients unable to receive general anesthesia (i.e. procedures performed under local anesthesia with or without sedation)
• Patients with severe hepatic insufficiency (Child-Pugh class C)
• Patients on total intravenous anesthesia (TIVA)

Where it is running

• Jewish General Hospital — Montreal, Quebec, Canada

Full record on ClinicalTrials.gov

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