CTG Versus Collagen Matrix for Peri-Implant Soft Tissue Augmentation

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Conditions studied: Peri-implant Soft Tissue Deficiency, Insufficient Peri-implant Keratinized Tissue

In brief

This randomized controlled trial compares two techniques for peri-implant soft tissue augmentation in the mandibular molar region: an autogenous connective tissue graft (CTG) and a collagen matrix. Adult patients requiring implant treatment with insufficient peri-implant soft tissue thickness will be randomly assigned to receive either CTG or a collagen matrix at the time of implant surgery. The study aims to evaluate and compare changes in peri-implant soft tissue thickness, width of keratinized tissue, and soft tissue contour over a 9-month follow-up period, as well as the occurrence of postoperative complications. The results of this study will help determine whether a collagen matrix can provide clinical outcomes comparable to those of connective tissue grafting for peri-implant soft tissue augmentation.

Key facts

Study ID

NCT07371481

Run by

Hanoi Medical University

People needed

46

Starts

2026-02-01

Expected to finish

2028-12-01

Last updated by the study team

2026-01-29

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adults aged 18 to 65 years.
• Patients requiring dental implant treatment in the mandibular molar region.
• Presence of insufficient peri-implant soft tissue thickness (< 2 mm).
• Adequate general health to undergo minor oral surgery.
• Ability and willingness to provide written informed consent and comply with study procedures.

You may not qualify if…

• Systemic conditions or medications that may impair wound healing.
• Heavy smoking (more than 10 cigarettes per day).
• History of allergy or hypersensitivity to collagen-based materials.
• Previous graft failure or complications at the intended implant site.
• Loss of three or more adjacent teeth in the study area (excluding third molars).

Where it is running

• Hanoi Medical University — Hanoi, Vietnam

Full record on ClinicalTrials.gov

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