Ketamine Irrigation Analgesia in Laparoscopic Cholecystectomy

Starting soon · Phase 3

Conditions studied: Pain

In brief

Patients will be assigned randomly to two groups (30 subjects each) to be anesthetized. The study drug will be delivered in opaque bags labeled "study drug" and 60 patients will be allocated in two groups (of 30 patients each) to receive the irrigation at the end of surgery after dissection; irrigation analgesia by 5 ml bupivacaine 0.50% plus 20 ml normal saline (Group N) or 5 ml bupivacaine 0.50% plus 1 mg/kg ketamine (Group K). The volume of irrigation in group K is completed by normal saline to reach a total of 25 ml.

Key facts

Study ID

NCT07370181

Run by

Assiut University

People needed

60

Starts

2026-01-30

Expected to finish

2026-07-10

Last updated by the study team

2026-01-27

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients with age ≥18 years of ASA I-II who will be scheduled for elective laparoscopic cholecystectomy under general anesthesia.

You may not qualify if…

• History of congenital heart disease
• Hypertension
• Developmental delay, or
• Allergy to study drugs

Full record on ClinicalTrials.gov

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