Environmental Reservoirs of Non-tuberculous Mycobacteria in Cystic Fibrosis Households: A Case-control Study of Exposure Risk at Home

Recruiting now

Conditions studied: Cystic Fibrosis (CF), Mucoviscidosis, Non-Tuberculous Mycobacteria, Mycobacterium Abscessus Infection

In brief

This multicenter, non-interventional case-control study investigates whether household environmental reservoirs, particularly water systems, are associated with non-tuberculous mycobacterial (NTM) infections in people with cystic fibrosis. Environmental samples from the homes of CF patients with and without NTM infection will be analyzed and genetically compared with available clinical isolates, alongside assessment of environmental risk factors, to improve understanding of exposure pathways and inform future prevention strategies.

Key facts

Study ID

NCT07369414

Run by

Research Center Borstel

People needed

120

Starts

2026-01-01

Expected to finish

2030-12-01

Last updated by the study team

2026-01-27

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Confirmed diagnosis of cystic fibrosis (CF)
• No age restriction (including minors with consent from legal guardians)
• Written informed consent to participate in the study (or consent provided by a legal guardian for minors)
• In the case of an NTM infection: diagnosis according to ATS/IDSA criteria and availability of a clinical NTM isolate

You may not qualify if…

• Lack of capacity to provide informed consent, refusal to participate, or withdrawal of informed consent

Where it is running

• National and WHO-Supranational Reference Center for Mycobacteria, Research Center Borstel, Leibniz Lung Center — Borstel, Schleswig-Holstein, Germany (enrolling)
• Klinik für Pneumologie, Universitätsklinikum Essen — Essen, Germany

Full record on ClinicalTrials.gov

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