Active Oxygen Releasing Gel With Photodynamic Therapy in Treating Stage III Periodontitis
Recruiting now · Not applicable
Conditions studied: Stage III Periodontitis
In brief
Periodontitis is a serious gum disease that can damage the tissues supporting the teeth. The standard treatment is scaling and root planing of the teeth and roots. However, in some patients, this treatment alone may not fully control inflammation and harmful bacteria. This study aims to evaluate whether adding an active oxygen-releasing gel, with or without photodynamic therapy, improves treatment outcomes in patients with stage III periodontitis. The oxygen-releasing gel is applied to the gums and releases oxygen, which may help reduce harmful bacteria. Photodynamic therapy uses a light source together with a special dye to target and destroy bacteria and improve gingival health. In this randomized clinical trial, 42 patients with stage III periodontitis will be divided into three groups. One group will receive standard scaling and root planing (SRP) plus the oxygen-releasing gel. A second group will receive standard scaling and root planing (SRP)plus the gel and photodynamic therapy. The third group will receive standard scaling and root planing(SRP) only. Gum health will be evaluated by measuring gingival index, bleeding index, pocket depth, and supra crestal tissue attachment level at the start of the study and after one and three months. Microbiological samples from periodontal pockets will also be used to assess levels using quantitative Polymerase Chain Reaction (qPCR) for relative abundance of Treponema denticola and Porphyromonas gingivalis bacteria related to periodontal disease.
Key facts
- Study ID
- NCT07368699
- Run by
- Alexandria University
- People needed
- 42
- Starts
- 2025-01-26
- Expected to finish
- 2026-05-01
- Last updated by the study team
- 2026-04-28
Who can join
Age: 30 and older, up to 70. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients with periodontal diagnosis of stage III periodontitis
- Patients with residual periodontal pocket depth ≥4 mm ,CAL≥ 5mm with bone loss extending to middle third of root and beyond in radiography
- Bleeding on probing at least four sites at base-line
- Patients who didn't receive periodontal treatment for a minimum of 3 months prior to the examination.
- Patients of both sexes aged ≥30 and ≤70 years
You may not qualify if…
- Smokers or those with any other harmful habits such as pipe or vape smoking
- Patients with any systemic condition that will possibly affect the outcome of periodontal therapy i.e. (diabetic patients)
- Patients who have received any local or systemic anti-inflammatory medications or antibiotics within the last 6 months
- Pregnant or lactating women
- Patients with parafunctional habits
Where it is running
- Faculty of Dentistry, Alexandria University — Alexandria, Bab Sharq, Egypt (enrolling)
Full record on ClinicalTrials.gov
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