Topical Multivitamin Serum for Skin Heath

Recruiting now · Phase 4

Conditions studied: Aesthetic

In brief

Skin boosters are injectable and topical treatments designed to improve dermal quality and restore skin health. These products typically include hyaluronic acid formulations, biostimulatory agents, platelet-rich plasma (PRP), growth factors, and polynucleotides. Their growing use in aesthetic medicine is supported by their diverse mechanisms of action and routes of administration. One such category of interest includes polynucleotide-based therapies, most notably Polydeoxyribonucleotide (PDRN). Derived from the DNA of salmon or trout, PDRN exhibits dual regenerative and anti-inflammatory properties. Mechanistically, it promotes tissue repair by supplying nucleotides essential for DNA synthesis and activates adenosine A2A receptors, thereby enhancing angiogenesis and mitigating inflammation. Clinically, PDRN has been applied in aesthetic medicine for skin rejuvenation, where it improves elasticity, texture, and reduces fine lines, as well as in wound healing and scar remodeling, supporting its integration into advanced bioregenerative protocols. Among such agents, VAMP™ ADVANCED Topical Multivitamin Serum is formulated to improve hydration, elasticity, and overall skin radiance through a proprietary blend of amino acids, vitamins, and peptides. While preliminary data suggest potential benefits, robust peer-reviewed clinical studies remain limited. This study seeks to evaluate the efficacy of topical application of VAMP™ ADVANCED Topical Multivitamin Serum following microneedling in skin rejuvenation.

Key facts

Study ID

NCT07368686

Run by

Erevna Innovations Inc.

People needed

30

Starts

2026-02-01

Expected to finish

2027-03-01

Last updated by the study team

2026-02-05

Who can join

Age: 22 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Ability to adequately understand the verbal explanations and the written participant information provided in local language and ability and willingness to give consent to participate in the study. Signed and dated informed consent to participate in the study.
• Participant interested in improving skin quality.
• Immune-competent adult 22 years of age and older.
• Has intent to undergo treatment to improve appearance of the facial skin.
• Willingness to comply with pre-visit instructions, including shaving of facial area (for male participants), to allow for consistent biometric and photographic evaluations.
• If the participant is a female of childbearing potential, she agrees to use an acceptable form of effective birth control for the duration of the study and is willing to take a urine pregnancy test (UPT) at Baseline and prior to receiving any study treatment.
• Acceptable forms of effective birth control include:
• Barrier methods of contraception: Condom or occlusive cap (diaphragm or cervical caps) with spermicidal foam/gel/film/ cream/suppository;
• Bilateral tubal ligation;
• Combined oral contraceptives (estrogens and progesterone), implanted or injectable contraceptives on a stable dose for at least 28 days prior to Day 1;
• Hormonal or copper intra uterine device (IUD) inserted at least 28 days prior to Day 1;
• Vasectomized partner (in monogamous relationship) for at least 3 months prior to screening;
• Strict abstinence (at least one month prior to Baseline and agrees to continue for the duration of the study or use acceptable form of birth control).
• Negative UPT for women of childbearing potential at the Baseline visit.
• Stable lifestyle and skincare regimen for at least 4 weeks

You may not qualify if…

• Known or suspected allergy or hypersensitivity to any components of VAMP™ ADVANCED Topical Multivitamin Serum, including sodium hyaluronate, peptides, polynucleotides (e.g., PDRN), or excipients.
• Known allergy or intolerance to topical anesthetics or lidocaine.
• History of hypersensitivity reactions such as anaphylaxis, angioedema, or other severe allergic responses.
• History of hypertrophic scarring, keloid formation, or post-inflammatory hyperpigmentation following cosmetic treatments.
• Tattoos, piercings, or skin bleaching agents in the treatment area that may interfere with assessments, as judged by the Investigator.
• Participants with known pigmentary instability or history of adverse response to microneedling.
• Previous cosmetic or dermatologic procedures in the treatment area within the following time frames:
• Previous treatment with cross-linked hyaluronic acid dermal fillers in the treatment area within the last 12 months.
• Energy-based devices (laser, IPL, RF, ultrasound) in the last 6 months.
• Microneedling, dermabrasion, mesotherapy, or chemical peels in the last 6 months.
• Use of topical corticosteroids, retinoids, or depigmenting agents in the treatment area within the past 4 weeks.
• Current use of immunosuppressive therapy, systemic corticosteroids, or chemotherapy within the last 3 months.
• History of systemic autoimmune, collagen vascular, or bleeding disorders (e.g., lupus, scleroderma, thrombocytopenia).
• Current pregnancy, positive urine pregnancy test at screening, breastfeeding, or intent to become pregnant during the study.
• Participation in another clinical study within the past 30 days or concurrent participation in another interventional trial.
• Any condition, including psychological, cognitive, or behavioral concerns, that would interfere with the ability to give informed consent, follow the protocol, or comply with follow-up requirements.
• Initiation of a weight loss program or GLP-1 agonist therapy within 30 days before baseline or planned during study period.
• Active skin conditions exacerbated by microneedling or transepidermal delivery, including chronic dermatitis or impaired barrier function.
• Current participation by study personnel, immediate family members, or employees of the Sponsor.
• Known allergy to fish or seafood, including but not limited to salmon, due to the potential presence of PDRN derived from marine sources.
• History of cancer or previous radiation near or on the area to be treated.
• Heavy smokers, classified as smoking more than 12 cigarettes per day.
• Presence of any disease or lesions near or on the area to be treated, e.g.
• Inflammation, active or chronic infection in or near the treatment area
• Psoriasis, eczema, herpes zoster and acanthosis

Where it is running

• Erevna Innovations Inc. — Montreal, Quebec, Canada (enrolling)

Full record on ClinicalTrials.gov

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