Prevalence of Airway Closure

Recruiting now

Conditions studied: To Determine the Annual Prevalence of Airway Closure

In brief

The primary objective of this study is to describe the prevalence of airway closure during the total support phase of invasive mechanical ventilation in subjects admitted to an intensive care unit (ICU). The secondary objective is to analyze whether there are clinical-demographic and/or ventilatory characteristics associated with the presence of airway closure.

Key facts

Study ID

NCT07368491

Run by

Romina Belen Mattei

People needed

75

Starts

2025-09-01

Expected to finish

2026-12-01

Last updated by the study team

2026-03-13

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Patients over 18 years of age
• Requiring invasive mechanical ventilation within 48 to 72 hours after orotracheal intubation
• Hemodynamically stable (mean arterial pressure greater than 60 mmHg and/or norepinephrine less than 0.5 mcg/kg/min)
• Without respiratory muscle effort

You may not qualify if…

• Neumothorax
• Bronchopleural fistula
• Clinical evidence or suspicion of elevated intracranial pressure (greater than 18 mmHg)

Where it is running

• CMPFA Churruca-Visca — Buenos Aires, Buenos Aires, Argentina (enrolling)

Full record on ClinicalTrials.gov

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