Th Study Wants to Compare the Best Technique for Sinus Operation in CRSWNP

Recruiting now · Not applicable

Conditions studied: CRSWNP

In brief

This randomized controlled trial aims to compare the efficacy and safety of reboot surgery versus conventional full house FESS in patients with refractory CRSwNP, focusing on: 1\. Primary Outcome: * Compare 24-month recurrence rates (defined as endoscopic polyp score ≥2) 2. Secondary Outcomes: * Recurrence-free survival (time to first recurrence), Quality of life improvement (SNOT-22 scores), Reduction in systemic corticosteroid use, Complication rates (synechiae, bleeding, infection) and Cost-effectiveness of each approach

Key facts

Study ID

NCT07368361

Run by

Kafrelsheikh University

People needed

40

Starts

2026-01-01

Expected to finish

2026-09-01

Last updated by the study team

2026-05-28

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may not qualify if…

• eosinophilic granulomatosis with polyangiitis (EGPA) or severe systemic diseases (except controlled asthma or NSAID-exacerbated respiratory disease), neoplasms, vasoconstrictor abuse (e.g., oxymetazoline dependence), unilateral nasal inflammatory disease, bilateral inflammatory disease without polyps, or treatment with monoclonal antibodies in the past 12 months, Patients younger than 18 years of age and patients are unfit for general anesthesia.

Where it is running

• Kafrelsheikh Faculty of Medicine — Egypt, Kafrelsheikh, Canada (enrolling)

Full record on ClinicalTrials.gov

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