End-of-life Care in Mechanically Ventilated Patients: Impact of a Comprehensive Palliative Care Protocol in the Intensive Care Setting
Starting soon · Not applicable
Conditions studied: Palliative Care, Withdrawal of Life Support, Intensive Care Medicine, Sedation, Dying Process
In brief
The ARREVE-3 trial will evaluate whether a structured palliative care protocol can improve end-of-life management for mechanically ventilated ICU patients in whom a decision to withdraw life-sustaining therapies has been made. This cluster-randomized controlled trial compares protocol-based care with usual practice across participating centers. The intervention includes comprehensive guidance on symptom management, sedation, nursing care, withdrawal procedures, and family support, supported by standardized staff training. The primary endpoint is adherence to recommended end-of-life practices, while secondary outcomes assess patient comfort, communication with relatives, and the impact on families and healthcare professionals
Key facts
- Study ID
- NCT07368010
- Run by
- Nantes University Hospital
- People needed
- 720
- Starts
- 2026-01-10
- Expected to finish
- 2029-01-10
- Last updated by the study team
- 2026-01-26
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patient:
- Age ≥ 18 years
- ICU admission for more than 48 hours
- Receiving invasive mechanical ventilation
- A documented decision to withdraw life-sustaining therapies, made through a multidisciplinary collegial process and communicated to the designated surrogate decision-maker, family, or relatives
- At least one visit from a relative prior to the decision to withdraw life-sustaining therapies
- Provision of informed consent for study participation, or, if the patient lacks decision-making capacity, consent obtained from a relative or legally authorized representative
- Relative:
- Age ≥ 18 years
- Has received at least one medical update regarding the patient's clinical status from an ICU physician prior to the decision to withdraw life-sustaining therapies
- Has provided informed consent for study participation
You may not qualify if…
- Patient:
- Presence of a tracheostomy
- Brain death or involvement in an organ donation procedure
- Absence of any visit from a relative
- Subject to legal guardianship or other legal protection measures
- Incarcerated patient
- Participation in another interventional research study focused on end-of-life care
- Pregnant or breastfeeding woman
- Relative:
- Inability to understand or speak French
- Subject to legal guardianship or other legal protection measures
Where it is running
- CHU Nantes — Nantes, France
Full record on ClinicalTrials.gov
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