Histatin-1 Levels in Smokers and Non-smokers With Periodontitis Patients: A Comparative Study Before and After Nonsurgical Periodontal Therapy
Enrolling by invitation · Not applicable
Conditions studied: Periodontitis, Periodontal Diseases
In brief
This study evaluated the impact of smoking on salivary histatin-1 levels and clinical healing in 50 patients with unstable periodontitis (25 smokers and 25 non-smokers) undergoing non-surgical periodontal therapy (NSPT). By measuring clinical parameters like probing depth and clinical attachment level alongside ELISA-based protein analysis at baseline, one month, and three months post-treatment, the researchers sought to determine if the impaired wound healing typically seen in smokers correlates with a suppressed expression of this specific salivary protein.
Key facts
- Study ID
- NCT07367737
- Run by
- University of Baghdad
- People needed
- 50
- Starts
- 2025-05-01
- Expected to finish
- 2026-02-10
- Last updated by the study team
- 2026-01-26
Who can join
Age: any. Sex: male. Healthy volunteers: accepted.
You may qualify if…
- the present study required participants to be systemically healthy, with no history of systemic diseases such as diabetes mellitus, cardiovascular disease, or renal disease.
- Participants had not undergone periodontal treatment in the past six months or taken any medication in the last three months.
- They also needed to have at least 20 teeth and be diagnosed with moderate periodontitis, characterized by a PPD of 4-6 mm, generalized, unstable periodontitis.
You may not qualify if…
- the presence of intraoral plaque-retentive factors such as crowns, bridges, partial dentures, orthodontic appliances, furcation-involved teeth, overhanging restorations, and tooth anomalies.
- Patients who had received antibiotic therapy within the previous three months.
Where it is running
- university of Baghdad, college of dentistry — Baghdad, Medical City, Iraq
Full record on ClinicalTrials.gov
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