Assessment Of Guided Bone Regeneration Using Xenograft Mixed With Allogenic Bone Graft Versus Xenograft Mixed With Autogenous Graft For Augmentation Of Maxillary Alveolar Ridges

Recruiting now · Not applicable

Conditions studied: Guided Bone Regeneration

In brief

This study aims to evaluate the effect of Allogenic bone graft mixed with Xenograft in ratio 1:1, on the radiographic and histomorphometric assessment versus Autologous bone graft mixed with Xenograft in ratio 1:1 in maxillary deficient ridges، In guided bone regeneration of deficient edentulous maxillary ridges, will the application of Xenograft mixed with Allograft (1:1) be as effective as Xenograft mixed with Autogenous graft (1:1) in terms of dimensional ridge changes and Quality of newly formed bone? Evaluation of the patient's general condition of the oral cavity, to make sure it complies with the criteria required to be enrolled in the study in terms of oral hygiene and pathological conditions. A full thickness flap will be elevated with two releasing incisions, decortication of the buccal aspect of the ridge, placing of grafting material which will be covered by collagen pericardium membranes, tacks placement at the labial side to fix the membrane in place, horizontal mattress sutures as well as single interrupted and continuous with resorbable sutures for closure. Intervention group: will be filled with mixture of Xenogenic graft and the Allogenic bone graft chips. Control group: will be filled with mixture of Xenogenic graft and Autogenous bone particulate harvested either the ramus. For both groups, All the subjects will be taking CBCT at pre surgical and 6 months post surgical. outcomes : Bucco-Palatal horizontal bone gain, Alveolar ridge height, Percentage of new vital bone formation and Percentage of residual bone graft 6 months post-surgical.

Key facts

Study ID: NCT07367464
Run by: Cairo University
People needed: 32
Starts: 2024-06-01
Expected to finish: 2026-06-01
Last updated by the study team: 2026-04-14

Who can join

Age: 20 and older, up to 50. Sex: any. Healthy volunteers: accepted.

You may qualify if…

Age: 20-50 years.
Totally or partially edentulous maxillary ridges.
Patients with insufficient bone for an implant placement.
Residual alveolar width ranging from 2 to 4 mm.
Minimum of 10 mm vertical dimension to nasal floor or sinus floor.
Patients with healthy systemic condition (Medically free).
Adequate inter-arch space for placement of the implant prosthetic part.

You may not qualify if…

Pathological lesions in the defect site.
Systemic diseases that would interfere with bone metabolism. Uncontrolled diabetic patients.
Ongoing treatment or a history of recent chemotherapy or radiotherapy.
Patient with medical condition that contraindicates surgical procedures.
Patients on medication that may interfere with healing (Corticosteroids, Bisphosphonate, Chemo/radio therapy).
Patients with vertical bone deficiency.
Patients with habits that may jeopardize the implant longevity and affect the results of the study such as alcoholism or para-functional habits.

Where it is running

Faculty of Dentistry Cairo University — Cairo, Egypt (enrolling)

Full record on ClinicalTrials.gov

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