Clinical Characteristics, Frailty, and Prognostic Predictors in Patients Aged 75 and Older With Acute Coronary Syndrome

Recruiting now

Conditions studied: ST Elevation (STEMI) Myocardial Infarction, Non ST Elevation Myocardial Infarction (NSTEMI), Unstable Angina Pectoris

In brief

This study will evaluate clinical characteristics, frailty, and predictors of prognosis in patients aged 75 years and older who are hospitalized with acute coronary syndrome (ACS). The research includes both a retrospective and a prospective cohort. The aim is to determine whether frailty scores, combined with clinical and laboratory parameters available at admission, can improve risk prediction for complications and mortality compared with standard risk scores (TIMI, GRACE, Syntax). The study will also compare outcomes between patients treated with percutaneous coronary intervention (PCI) and those treated conservatively with medications. Patients will be followed during hospitalization and for six months after discharge. The results are expected to contribute to more personalized treatment strategies for elderly patients with ACS.

Key facts

Study ID

NCT07366684

Run by

Clinical Center Niš

People needed

550

Starts

2026-05-13

Expected to finish

2027-09-01

Last updated by the study team

2026-05-15

Who can join

Age: 75 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥ 75 years
• Diagnosis of acute coronary syndrome (STEMI, NSTEMI, or unstable angina)
• Hospitalization in a tertiary care center (University Clinical Center Niš)
• For prospective cohort: signed informed consent

You may not qualify if…

• Refusal to provide informed consent (prospective cohort)
• Missing or incomplete medical documentation (retrospective cohort)

Where it is running

• Clinical Center Niš — Niš, Serbia (enrolling)

Full record on ClinicalTrials.gov

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