Liver Cirrhosis Complicated by Clinically Significant Portal Hypertension

Starting soon · Not applicable

Conditions studied: Portal Hypertension, Spleen Disease, Cirrhosis

In brief

Portal hypertension is a major complication of cirrhosis. HVPG is the diagnostic gold standard but is invasive. Non-invasive tools such as spleen stiffness measurement (SSM) and CEUS show promise for assessing CSPH, though they have not yet been compared directly. A multimodal ultrasound approach may provide a reliable alternative to HVPG.

Key facts

Study ID

NCT07365709

Run by

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

People needed

107

Starts

2026-02-01

Expected to finish

2026-12-31

Last updated by the study team

2026-01-26

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Individuals of both sexes aged 18 years or over; Subjects diagnosed with liver cirrhosis. Subjects who have undergone hepatic venous pressure gradient (HVPG) measurement to assess portal hypertension, and/or show indirect clinical signs of significant portal hypertension, such as oesophageal varices or porto-systemic collateral circulation.
• Cirrhotic subjects who must undergo contrast-enhanced ultrasound as part of regular hepatological follow-up.
• Subjects who have given their informed consent.

You may not qualify if…

• Subjects aged under 18 years; Subjects with cholestatic disease Subjects diagnosed with clinically significant portal hypertension of non-cirrhotic aetiology.
• Subjects diagnosed with ascites Subjects diagnosed with splanchnic thrombosis Subjects presenting with spleno-portal flow reversal Subjects who are allergic to ultrasound contrast media Subjects who have not given their informed consent.

Full record on ClinicalTrials.gov

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