Platelet-Derived Growth Factors to Enhance Healing and Reduce Post-Extraction Complications in Smokers
Starting soon · Not applicable
Conditions studied: Smoke Exposure
In brief
This study is a randomized controlled clinical trial with a split-mouth design to evaluate the effect of Advanced Platelet-Rich Fibrin (A-PRF) application on socket healing following dental extractions in smokers. In the split-mouth design, each participant serves as their own control, minimizing inter-subject variability and controlling for potential confounders such as smoking habits, oral hygiene, and systemic health conditions. Bilateral tooth extractions will be performed for each participant, with one extraction site randomly assigned to receive socket preservation using an A-PRF plug, while the contralateral site will be left to heal naturally without intervention. The study will be conducted at the Faculty of Dentistry and the University Dental Hospital, King Abdulaziz University, Jeddah, Saudi Arabia. Recruitment began in December 2025 and will continue until the targeted sample size is achieved.
Key facts
- Study ID
- NCT07364890
- Run by
- King Abdulaziz University
- People needed
- 12
- Starts
- 2026-01-31
- Expected to finish
- 2026-06-30
- Last updated by the study team
- 2026-01-23
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Smokers
- Aged 18 years or older
- Actively smoking at least 10 cigarettes per day
- Requiring bilateral extractions.
You may not qualify if…
- Patients younger than 18 years
- Diabetes mellitus
- Hypertension
- Bleeding disorders
- Pregnant or lactating women
- Individuals who used tobacco products other than conventional cigarettes (such as e-cigarettes or waterpipes) were excluded.
Where it is running
- King AbdulAziz University — Jeddah, Mekkah, Saudi Arabia
Full record on ClinicalTrials.gov
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