Non-Invasive Preimplantation Genetic Screening for Aneuploidies and Clinical Outcomes in Egg Donation Patients

Recruiting now

Conditions studied: IVF

In brief

Preimplantation genetic testing for aneuploidies (PGT-A) is commonly used in IVF but requires embryo biopsy and shows limited benefit in egg donation cycles. Non-invasive PGT-A (niPGTA), based on the analysis of cell-free embryonic DNA in spent culture media, offers a promising biopsy-free alternative. This prospective, blinded study in egg donation cycles will evaluate whether niPGTA-detected aneuploidy is associated with implantation failure and pregnancy loss, assessing its potential clinical value as a non-invasive embryo selection tool.

Key facts

Study ID

NCT07364526

Run by

Instituto Bernabeu

People needed

164

Starts

2026-02-26

Expected to finish

2027-12-01

Last updated by the study team

2026-01-23

Who can join

Age: 18 and older, up to 50. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Women between 18 and 50 years old who are oocyte recipients.
• Signed consent form
• Transfer of a single blastocyst-stage embryo
• Male with normal sperm FISH

You may not qualify if…

• Uterine malformations
• Abnormal karyotypes in either partner
• Failure to sign informed consent

Where it is running

• Instituto Bernabeu — Alicante, Spain (enrolling)

Full record on ClinicalTrials.gov

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