Coronary Computed Tomography Angiography In Rheumatoid Arthritis Study

Enrolling by invitation

Conditions studied: Rheumatoid Arthritis, Atherosclerotic Ischemic Disease, Pulmonary Disease, Depressive Disorder, Anxiety Disorders, Cardiovascular and Respiratory Disease, Cardiovascular Biomarkers, Cardiovascular (CV) Risk, Cardiovascular Disease, Cardiovascular Disease (CKD), Cardiovascular Disease (CVD) Risk Factors, COPD (Chronic Obstructive Pulmonary Disease), Pulmonary Diseases or Conditions, Pulmonary Disease, Chronic Obstructive, Depressive and Anxiety Disorders, Interstitial Lung Disease in Patients With Rheumatoid Arthritis, Lung Cancer (Diagnosis)

In brief

The Coronary Computed Tomography Angiography in Rheumatoid Arthritis study is part of the multinational, prospective, observational Autoimmunity and Atherosclerosis in Rheumatic Diseases cohort (https://atacc-rd.com) that includes comprehensive baseline and follow-up assessments at 3, 5, and 10 years. It comprises a main protocol and several optional modules, including a Cardiac Imaging Module, Biobanking Module, Pulmonary Module, and Anxiety and Depression Module. The study aims to advance understanding of cardiopulmonary and psychological comorbidities in rheumatoid arthritis, to improve early identification and management, and to enhance insights into underlying disease mechanisms-ultimately refining risk stratification and targeted prevention strategies. The study includes 4,000 patients with rheumatoid arthritis enrolled through the Cardiac Imaging Module in the main protocol. Participants undergo coronary computed tomography angiography, pulmonary function testing, physical examination, questionnaires, and biobanking, supplemented by genetic, proteomic, metabolomic, and microbiome profiling.

Key facts

Study ID

NCT07363980

Run by

Ellen Margrethe Hauge

People needed

4000

Starts

2024-02-21

Expected to finish

2040-12-31

Last updated by the study team

2026-02-03

Who can join

Age: 50 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Fulfill the ACR/EULAR-2010 criteria for rheumatoid arthritis
• Attending or has attended at least one visit during the last two years in rheumatology outpatient clinic for diagnostic or monitoring purposes related to rheumatoid arthritis
• Age 50-75 years

You may not qualify if…

• Diagnosed with overlapping systemic autoimmune diseases other than secondary Sjogren's syndrome
• Active cancer
• Prior coronary atherosclerotic symptoms as defined by myocardial infraction, percutaneous coronary intervention, or coronary artery bypass grafting
• Allergy to radiocontrast agents
• Estimated glomerular filtration rate (eGFR) < 30 mL/min
• BMI > 35 kg/m2
• Persistent atrial fibrillation

Where it is running

• Aarhus University Hospital — Aarhus, Denmark
• Esbjerg Hospital — Esbjerg, Denmark
• Regional Hospital Gødstrup — Herning, Denmark
• Silkeborg Regional Hospital — Herning, Denmark

Full record on ClinicalTrials.gov

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