A Study on the Correlation Between Tear Iron Levels and the Severity of Dry Eye Disease.

Recruiting now

Conditions studied: Dry Eye Disease, Iron

In brief

This study aims to see if the amount of iron in tears is linked to how severe dry eye disease is. We hope this can lead to a new way to help diagnose and understand dry eye. This is an observational study. We will compare tear samples from people with dry eye to samples from people with healthy eyes. We will measure the iron content in the tears and see if it correlates with standard dry eye test results and symptom scores.

Key facts

Study ID: NCT07363824
Run by: Shanghai Changzheng Hospital
People needed: 52
Starts: 2026-02-06
Expected to finish: 2029-05-01
Last updated by the study team: 2026-02-10

Who can join

Age: 18 and older, up to 70. Sex: any. Healthy volunteers: accepted.

You may qualify if…

Aged between 18 and 70 years, inclusive.
Willing and able to provide written informed consent.

You may not qualify if…

History or clinical suspicion of significant systemic conditions: hematologic diseases, severe systemic infections, malignancies (treated or untreated), or chronic hepatic/renal insufficiency.
Use of artificial tears or any topical eye drops within 2 hours prior to examination.
Active ocular allergy, infection, or severe blepharitis within the past 1 month.
Systemic or topical use of antibiotics, corticosteroids, NSAIDs, or immunosuppressants within the past 1 month.
History of contact lens wear within the past 1 month.
History of blood transfusion, ocular surgery, or significant ocular trauma within the past 6 months.
Women who are pregnant, breastfeeding, or postmenopausal women undergoing hormone replacement therapy.
Known hypersensitivity to fluorescein sodium.

Where it is running

Changzheng Hospital — Shanghai, China (enrolling)

Full record on ClinicalTrials.gov

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