Large Granular Lymphocytes in mNSCLC Treated With Nivolumab

Recruiting now

Conditions studied: Metastatic NSCLC - Non-Small Cell Lung Cancer

In brief

Large granular lymphocytes (LGLs), which constitute 10-15% of peripheral blood mononuclear cells, are large lymphocytes with a round nucleus, large cytoplasm, and azurophilic granules in the cytoplasm. Most normal LGLs in peripheral blood are natural killer (NK) cells, but some are T lymphocytes. These cells cannot be measured by a standard complete blood count (CBC) test. These cells, which can be detected by peripheral smear, are expressed numerically and as a percentage relative to other cells. The aim of this study is to determine the relationship between the percentage of LGLs at baseline and at three months and the response and clinical parameters in participants with metastatic non-small cell lung cancer treated with nivolumab in second-line therapy.

Key facts

Study ID: NCT07363811
Run by: Necmettin Erbakan University
People needed: 50
Starts: 2025-07-01
Expected to finish: 2027-06-01
Last updated by the study team: 2026-01-26

Who can join

Age: 18 and older, up to 90. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Histological and staging diagnosis of metastatic non-small cell lung cancer
ECOG performance score between 0 and 2
No contraindications for nivolumab

You may not qualify if…

Patients diagnosed with mNSCLC who received nivolumab as adjuvant or perioperative therapy
Those with a second primary malignancy undergoing active treatment
Those who have not signed the informed consent form
Those with additional hematological malignancies such as leukemia, lymphoma, or myelodysplastic syndrome
Those who have undergone palliative or curative radiotherapy within the last three months
Those with active viral/bacterial infections before nivolumab treatment
Patients who have used steroids in the last three months

Where it is running

Necmettin Erbakan University Faculty of Medicine, Department of Medical Oncology — Konya, Meram, Turkey (Türkiye) (enrolling)

Full record on ClinicalTrials.gov

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