A Study to Learn About the Study Medicine Called PF-07275315 in People With Moderate to Severe Chronic Obstructive Pulmonary Disease
Recruiting now · Phase 2/Phase 3 · Has a placebo group
Conditions studied: Moderate to Severe Chronic Obstructive Pulmonary Disease
In brief
The purpose of this clinical trial is to learn about the effects and safety of the study medicine PF-07275315 for the potential treatment of COPD. COPD is a condition that makes it difficult to breathe, which negatively impacts the quality of life and functioning of people who are affected. This study is seeking participants who: * Are 35 to 80 years old * Have had moderate-to-severe COPD for at least 12 months * Have a documented history of at least 2 moderate or severe exacerbations within the last 12 months * Have been continuously taking their regular maintenance treatment(s) for COPD over at least 6 months at a stable dose for 3 months All participants will receive PF-07275315 or a placebo. A placebo does not have any medicine in it but looks just like the medicine being studied. PF-07275315 or placebo will be given as multiple shots in the clinic over the course of 24 weeks for the Phase 2 part and 52 weeks for the Phase 3 part. We will compare the results of people receiving PF-07275315 to those of the people who do not. This will help us determine if PF-07275315 is safe and effective. Participants who will be involved in the Phase 2 part of the study for about 40 weeks. During this time, they will have 11 visits at the study clinic. Participants who will be involved in the Phase 3 part of the study for about 68 weeks. During this time, they will have 18 visits at the study clinic.
Key facts
- Study ID
- NCT07363694
- Run by
- Pfizer
- People needed
- 1156
- Starts
- 2026-02-11
- Expected to finish
- 2031-01-16
- Last updated by the study team
- 2026-07-27
Who can join
Age: 35 and older, up to 80. Sex: any. Healthy volunteers: not accepted.
Where it is running
- University of Alabama at Birmingham Lung Health Center — Birmingham, Alabama, United States (enrolling)
- Pulmonary Associates of Mobile, P.C. — Mobile, Alabama, United States (enrolling)
- SEC Clinical Research — Dothan, Alabama, United States (enrolling)
- Pulmonary Associates, PA — Phoenix, Arizona, United States (enrolling)
- IMAX Clinical Trials — La Palma, California, United States (enrolling)
- NewportNativeMD, Inc. — Newport Beach, California, United States (enrolling)
- California Medical Research Associates — Northridge, California, United States (enrolling)
- Institute of HealthCare Assessment d/b/a Apex Clinical Research — San Diego, California, United States (enrolling)
- Finlay Medical Research — Greenacres City, Florida, United States (enrolling)
- Clinical Research Specialists LLC — Kissimmee, Florida, United States (enrolling)
- Advanced Pulmonary Research Institute — Loxahatchee Groves, Florida, United States (enrolling)
- Reed Medical Research — Miami, Florida, United States (enrolling)
- Renstar Medical Research — Ocala, Florida, United States (enrolling)
- HCA Florida Ocala Imaging Center — Ocala, Florida, United States (enrolling)
- Ocala Lung and Critical Care Associates — Ocala, Florida, United States (enrolling)
- Renstar Medical Research — Ocala, Florida, United States (enrolling)
- Coastal Medical Research Institute, LLC — St. Petersburg, Florida, United States (enrolling)
- Coastal Pulmonary and Critical Care, P.L.C — St. Petersburg, Florida, United States (enrolling)
- Clinical Research Trials of Florida, Inc. — Tampa, Florida, United States (enrolling)
- Clinical Site Partners, LLC dba Flourish Research — Winter Park, Florida, United States (enrolling)
- Cpcc-Research Llc — East Point, Georgia, United States (enrolling)
- Centricity Research Rincon Pulmonology — Rincon, Georgia, United States (enrolling)
- ASHA Clinical Research - Munster, LLC — Hammond, Indiana, United States (enrolling)
- Methodist Hospital Southlake — Merrillville, Indiana, United States (enrolling)
- Southern Clinical Research, LLC — Zachary, Louisiana, United States (enrolling)
Full record on ClinicalTrials.gov
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