TMS-Induced LH Response in Healthy Women in Luteal Phase

Running, not enrolling · Not applicable · Has a placebo group

Conditions studied: Healthy Women

In brief

The purpose of this research is to establish whether non-invasive Transcranial Magnetic Stimulation (TMS), can affect modulation of hormones such: Luteinizing Hormone (LH) and Follicle-stimulating hormone (FSH). The hypothesis is that applying TMS to the Dorsolateral Prefrontal Cortex with specific pulse patterns, mimicking endogenous Gonodotropin-Releasing Hormone (GnRH) pulses that are known to stimulate LH secretion may modulate hormonal levels.

Key facts

Study ID

NCT07363421

Run by

The City College of New York

People needed

10

Starts

2026-02-24

Expected to finish

2026-06-01

Last updated by the study team

2026-04-27

Who can join

Age: 22 and older, up to 40. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Healthy women aged 22-40 years with regular menstrual cycle.
• In luteal phase at the time of visit.

You may not qualify if…

• Presence of any known structural brain abnormalities or tumors.
• Presence of metal implants/devices in the head or neck.
• Has ever had a stroke, seizure, or has a family history of epilepsy.
• Head injury with loss of consciousness.
• Use of hormonal contraceptives in the past 3 months.
• Irregular menstrual cycles.
• Diagnosed with a reproductive system disorder (e.g., PCOS, endometriosis, infertility, hypogonadism).
• History of endocrine disorders such diabetes mellitus, thyroid disease, adrenal disorders, pituitary tumor or others.
• Been diagnosed or received treatment for depression, anxiety disorder, schizophrenia, PTSD or bipolar disorder.
• Have a history of medical disorder such liver or renal impairment, HIV/AIDS or unstable cardiac disease.
• Taking any medications that affect the central nervous system such as antidepressents, antipsychotics, GLP-1 receptor agonists or hormone therapies.
• Are you pregnant, planning pregnancy or breastfeeding.
• Have experienced difficulties in the past during blood draws such as locating the vein, fainting or other adverse reactions.
• Have any sleep disorder such as insomnia or sleep apnea.
• Have fear of needles or the sight of blood.
• Underwent TMS stimulation in the past and had difficulties.

Where it is running

• Site 1 — New York, New York, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.