Nifedipine and Enalapril vs Nifedipine and Labetalol for the Treatment of Postpartum Hypertension Study

Recruiting now · Not applicable

Conditions studied: Hypertension, Postpartum Preeclampsia

In brief

To determine if nifedipine and enalapril will have better blood pressure control in the postpartum setting compared to nifedipine and labetalol.

Key facts

Study ID

NCT07363343

Run by

The Cleveland Clinic

People needed

200

Starts

2026-03-10

Expected to finish

2029-12-31

Last updated by the study team

2026-08-03

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Postpartum women aged 18 years or older
• Clinical diagnosis of hypertensive disorder in pregnancy (gestational hypertension, chronic hypertension, preeclampsia with or without severe features)
• Taking Nifedipine 60 mg every 12 hours for blood pressure control
• Persistently elevated blood pressure at/above 140/90 mmHg in a 24-hour time period or have one or more severe range blood pressure at/above 160/110 mmHg requiring a second antihypertensive medication
• English speaking

You may not qualify if…

• Taking ≥2 antihypertensive agents during pregnancy
• Heart block
• Heart rate <60 or >120 beats per minute
• Heart failure
• Creatinine >1.5 mg/dL
• Renal artery stenosis
• Active connective tissue disease
• Cerebrovascular accident
• Failed treatment or contraindications to nifedipine, enalapril or labetalol

Where it is running

• Cleveland Clinic — Cleveland, Ohio, United States (enrolling)

Full record on ClinicalTrials.gov

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