A Comparative Study of Intradialytic vs. Pre-Dialysis Physical Therapy Interventions in Individuals Undergoing Hemodialysis: A Randomized Controlled Trial

Recruiting now · Not applicable

Conditions studied: End-stage Renal Disease (ESRD), Chronic Kidney Disease, Hemodialysis Patients, Physical Rehabilitation During Dialysis

In brief

This randomized controlled trial aims to compare the effectiveness of two different timings of physical therapy for individuals undergoing hemodialysis: intradialytic (during dialysis) and pre-dialysis (before dialysis). The study seeks to determine which approach provides better improvements in physical function, quality of life, and biochemical outcomes such as hemoglobin and electrolyte levels. A total of 72 adult participants with end-stage renal disease (ESRD) receiving hemodialysis will be randomly assigned to one of two groups. Both groups will receive standardized educational sessions on the benefits and safety of exercise before beginning the intervention. Participants in the intradialytic group will perform supervised exercises during their dialysis sessions, while those in the pre-dialysis group will complete similar exercises before their dialysis sessions. Each participant will undergo the intervention twice per week for 12 weeks. Primary outcomes include physical function, assessed using the Six-Minute Walk Test and the Five Times Sit-to-Stand Test. Secondary outcomes include hemoglobin levels, electrolyte balance, and health-related quality of life measured by the KDQOL questionnaire. The study will be conducted at Mubarak Al-Abdullah Al-Jaber Al-Sabah Dialysis Center, Kuwait, following ethical approval from the Ministry of Health Research Ethics Committee. The results are expected to inform best practices for integrating physical therapy into dialysis care to enhance the health, safety, and well-being of individuals undergoing hemodialysis.

Key facts

Study ID

NCT07361146

Run by

Mohammad Arian

People needed

72

Starts

2025-03-02

Expected to finish

2027-06-02

Last updated by the study team

2026-01-22

Who can join

Age: 21 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adults aged between 21 and 65 years.
• Diagnosed with end-stage renal disease (ESRD).
• Undergoing maintenance hemodialysis for at least 3 months.
• Medically stable and cleared by the nephrologist to participate in moderate physical exercise.
• Able to understand and follow verbal instructions and provide informed consent.

You may not qualify if…

• Uncontrolled hypertension, recent myocardial infarction, or unstable angina.
• Severe musculoskeletal, neurological, or cardiovascular disorders that limit physical activity.
• Active infection, fever, or open wounds.
• Recent hospitalization within the past month.
• Participation in any other structured exercise program within the last 3 months.

Where it is running

• Mubarak Al-Abdullah Al-Jaber Al-Sabah Dialysis Center — Hawalli, Kuwait (enrolling)

Full record on ClinicalTrials.gov

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