Cyclophosphamide and Etoposide as a Metronomic Therapy in Advanced Head and Neck Squamous Cell Cancer

Starting soon · Phase 2

Conditions studied: Squamous Cell Carcinoma, Advanced Head and Neck Cancer

In brief

The goal of this clinical trial is to learn if drugs as cyclophosphamide (C) and etoposide (E) work to treat advanced head and neck cancer in adults. It will also learn about the safety of both drugs. The main questions it aims to answer are: Do drugs C and E work to treat advanced head and neck cancer, after failure on first line chemotherapy? What medical problems do participants have when taking drugs C and E? Researchers will compare drugs C and E in combination to a placebo (a look-alike substance that contains no drug) to see if these 2 drugs works to treat advanced head and neck cancer. Participants will: Take drug C every 3 weeks and drug E every 4 weeks or a placebo every week for 6 months. Visit the clinic once every 3 weeks for checkups and tests. Keep a diary of their symptoms.

Key facts

Study ID

NCT07361133

Run by

National Cancer Institute, Egypt

People needed

120

Starts

2026-04-01

Expected to finish

2026-09-01

Last updated by the study team

2026-04-16

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult participants, age = or > 18 years
• Participants with recurrent head and neck squamous cell carcinoma after failure on first line chemotherapy.
• Participants with advanced progressed, resistant, metastatic head and neck squamous cell carcinoma.

You may not qualify if…

• Adjuvant and Neoadjuvant head and neck squamous cell carcinoma patients.

Where it is running

• National Cancer Institute — Cairo, Cairo Governorate, Egypt

Full record on ClinicalTrials.gov

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