Prediction of Postoperative Pulmonary Complications in Thoracic Surgery

Starting soon

Conditions studied: Postoperative Pulmonary Complications (PPCs)

In brief

Lung cancer is a common disease, and its treatment is lobectomy or pulmonary segmentectomy. In France, approximately 8,000 patients undergo this procedure each year, but it remains associated with significant Postoperative Pulmonary Complications (PPC). This surgical trauma triggers a multicellular and orchestrated immune response, necessary for defense against pathogens, as well as for inflammatory resolution and wound healing. Preoperative single-cell analysis of the patient's immune system is therefore a promising strategy for identifying biomarkers of postoperative pulmonary complications (PPC). Brice Gaudilliere's laboratory at Stanford University, in collaboration with the Paris-based startup Surge, has developed and patented a multivariate model integrating mass cytometry data, proteomic analyses, and clinical data collected before surgery to accurately predict surgical site complications after major abdominal surgery. However, no study has yet explored the identification of inflammatory biomarkers predictive of PPC after thoracic surgery.

Key facts

Study ID

NCT07359885

Run by

University Hospital, Rouen

People needed

100

Starts

2026-06-01

Expected to finish

2029-03-01

Last updated by the study team

2026-01-22

Who can join

Age: 18 and older, up to 99. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥ 18 years
• ASA score ≤ 3
• Patients undergoing scheduled video-assisted or robot-assisted lobectomy, bilobectomy, or segmentectomy.
• Patients who have read and understood the information letter and do not object to the research.
• For women of childbearing age (non-sterile): effective contraception
• Menopausal (non-medically induced amenorrhea for at least 12 months)
• Patients covered by a social security scheme

You may not qualify if…

• Minor patients
• Surgery scheduled for a Friday
• Patients undergoing a pneumonectomy
• Pregnant or breastfeeding women
• Patients deprived of their liberty by an administrative or judicial decision, as well as those under legal protection, guardianship, or curatorship

Where it is running

• Service de Anesthésie-Réanimation Médecine périopératoire CHU de Rouen — Rouen, France

Full record on ClinicalTrials.gov

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