Multimodal Analysis of Endomyocardial Biopsies

Recruiting now

Conditions studied: Heart Transplantation, Dilated Cardiomyopathy (DCM), Hypertrophic Cardiomyopathy (HCM), Myocarditis, Pericarditis, Amyloidosis Cardiac, Cardiomyopathies, Sarcoidosis of the Heart

In brief

The goal of this observational study is to pursue a multimodal approach to identify the molecular signatures and immune signalling molecules of various myocardial diseases and thereby contribute to improving diagnosis and therapy. The main aim is: -Identification of molecular profiles (e.g., proteome, lipidome, metabolome) and immune signalling profiles that are specifically associated with different myocardial diseases and the post-heart transplantation course. Participants already receiving an endomyocardial biopsy as part of their regular medical care will be enrolled. An additional biopsy sample will be taken for the above mentioned research.

Key facts

Study ID: NCT07359690
Run by: University Hospital, Essen
People needed: 216
Starts: 2025-10-27
Expected to finish: 2028-09-30
Last updated by the study team: 2026-01-22

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Patients aged >18 years with a clinical indication for endomyocardial biopsy.
Patients capable of providing informed consent who have signed the consent form for participation in the study.

You may not qualify if…

Patients without a clinical indication for endomyocardial biopsy (EMB).
Pregnant individuals.
Patients incapable of providing informed consent.
Women of childbearing potential who are not using adequate contraception.

Where it is running

Department of Cardiology and Vascular Medicine, West German Heart and Vascular Center Essen, University Hospital Essen, Germany — Essen, North Rhine-Westphalia, Germany (enrolling)

Full record on ClinicalTrials.gov

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