Lidocaine vs Magnesium Sulfate for Hemodynamic Stability During Emergence in Infertility-Related Laparoscopic Surgery"

Starting soon · Not applicable

Conditions studied: Infertility Female, Hemodynamic Instability

In brief

This study is being conducted to compare two medications, intravenous lidocaine and intravenous magnesium sulfate, and their ability to keep blood pressure and heart rate stable during the period of waking up from general anesthesia in infertility-related laparoscopic gynecologic surgeries. Laparoscopic gynecologic procedures can cause changes in heart rate and blood pressure, especially during emergence from anesthesia, and these changes may affect patient safety. In this randomized, double-blind clinical trial, women scheduled for elective infertility-related laparoscopic surgery will be assigned to one of three groups: lidocaine, magnesium sulfate, or a control group. The study will evaluate mean arterial pressure (primary outcome), heart rate, pain scores, sedation level, nausea and vomiting, and any side effects during and after surgery. The goal is to determine which medication provides better hemodynamic stability and improves recovery in the early postoperative period.

Key facts

Study ID

NCT07359560

Run by

Zagazig University

People needed

69

Starts

2026-01-02

Expected to finish

2026-07-02

Last updated by the study team

2026-01-22

Who can join

Age: 21 and older, up to 40. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Female patients aged 21 to 40 years
• Body mass index (BMI) between 18.5 and 29 kg/m²
• American Society of Anesthesiologists (ASA) physical status I or II
• Scheduled for elective infertility-related laparoscopic gynecologic surgery (e.g., diagnostic laparoscopy, ovarian cystectomy, adhesiolysis) under general anesthesia
• Expected duration of anesthesia less than 2 hours
• Ability to provide written informed consent

You may not qualify if…

• Known allergy or contraindication to lidocaine or magnesium sulfate
• History of significant cardiac, renal, or hepatic disease
• Chronic use of analgesics or history of drug dependence
• History of myasthenia gravis
• Pregnancy or positive serum β-hCG test

Where it is running

• Zagazig University Faculty of Medicine — Zagazig, Egypt

Full record on ClinicalTrials.gov

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