Postoperative Assessment of Platelet-Rich Plasma and Platelet-Rich Fibrin in Temporomandibular Joint Surgery

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Conditions studied: Temporomandibular Joint Disorders

In brief

The goal of this observational study is to evaluate postoperative outcomes following temporomandibular joint (TMJ) surgery and to compare the effectiveness of intraoperative platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) injections in patients with temporomandibular joint disorders. The study includes adult patients who underwent TMJ surgery and received either PRP or PRF intraoperatively. The main questions this study aims to answer are: Whether intraoperative PRP or PRF injection is associated with differences in postoperative pain intensity and recovery. Whether PRP and PRF differ in their effects on postoperative jaw function, including maximum mouth opening and joint symptoms. If there is a comparison group: Researchers will compare patients who received intraoperative PRP with those who received intraoperative PRF to assess differences in postoperative pain, functional outcomes, and joint-related symptoms. Participants will: Have their existing medical records reviewed retrospectively. Provide postoperative outcome data derived from routine clinical follow-up, with no prospective recruitment or intervention.

Key facts

Study ID

NCT07359131

Run by

Jingping Wang, MD, Ph.D.

People needed

700

Starts

2026-11-15

Expected to finish

2027-12-05

Last updated by the study team

2026-06-09

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients aged 18 to 75 years (inclusive)
• Underwent unilateral or bilateral temporomandibular joint (TMJ) arthroscopy
• Received intraoperative platelet-rich plasma (PRP) or platelet-rich fibrin (PRF) injection during TMJ arthroscopy

You may not qualify if…

• Age younger than 18 years or older than 75 years
• Did not undergo TMJ arthroscopy
• Did not receive intraoperative PRP or PRF injection
• Incomplete clinical or follow-up data

Where it is running

• Meikun Wang — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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