Liquid Biopsy-Based Pre-Screening to Streamline LDCT Lung Cancer Screening in High-Risk Individuals

Recruiting now · Not applicable

Conditions studied: Lung Cancer, Lung Neoplasms, Early Lung Cancer Detection, Cancer Screening, High-Risk Populations

In brief

This study evaluates the feasibility and cost-effectiveness of using a blood-based liquid biopsy assay as a pre-screening tool before low-dose CT (LDCT) for lung cancer screening. By identifying individuals unlikely to have lung cancer, this approach aims to reduce unnecessary LDCT scans, radiation exposure, and healthcare costs, while improving early detection, particularly among high-risk individuals including never-smokers with a family history of lung cancer.

Key facts

Study ID

NCT07358715

Run by

National University Hospital, Singapore

People needed

140

Starts

2024-11-01

Expected to finish

2028-12-31

Last updated by the study team

2026-01-22

Who can join

Age: 21 and older, up to 75. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• High-Risk Individuals (n = 100)
• No prior history of lung cancer
• Meets one of the following high-risk definitions:
• Current or former smoker (quit within the past 15 years), aged 55-74 years, with a smoking history of ≥30 pack-years; OR
• Never-smoker aged 55-75 years with a first-degree family history of lung cancer
• Able and willing to provide written informed consent
• Early-Stage Lung Cancer Patients (n = 20)
• Aged ≥21 years
• Histologically or clinically confirmed stage I-II lung cancer
• Treatment-naïve (no prior surgery, chemotherapy, radiotherapy, or immunotherapy for lung cancer)
• Able and willing to provide written informed consent
• Advanced-Stage Lung Cancer Patients (n = 20)
• Aged ≥21 years
• Histologically or clinically confirmed stage III-IV lung cancer
• Treatment-naïve (no prior systemic or local therapy for lung cancer)
• Able and willing to provide written informed consent

You may not qualify if…

• Applicable to All Participants
• Pregnant or breastfeeding women
• Inability or unwillingness to comply with study procedures
• High-Risk Individuals Only
• Known allergy or contraindication to CT contrast agents
• Prior low-dose CT (LDCT), CT thorax, or PET-CT performed within 12 months prior to enrollment
• Lung Cancer Cohorts Only
• Receipt of any prior cancer-directed treatment for lung cancer

Where it is running

• National University Hospital Singapore — Singapore, Singapore (enrolling)

Full record on ClinicalTrials.gov

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