Treatment Outcomes for Portal Hypertension Esophageal and Gastric Varices

Recruiting now

Conditions studied: Esophagogastric Varices, Portal Hypertension

In brief

This study is a single-center, prospective cohort study based on real-world data. Patients with portal hypertension and esophagogastric varices were enrolled and divided into an endoscopic treatment group and a non-endoscopic treatment group (including patients receiving medical therapy, interventional procedures, or surgical treatment) according to whether they underwent endoscopic intervention. Baseline data, serum metabolites, CT imaging and endoscopic images, liver biopsy pathology, and other multi-omics data were integrated for both groups. Patients were followed up to compare adverse events after variceal treatment, including rebleeding and its causes, hepatic encephalopathy, ascites, subsequent treatments (such as regular endoscopic therapy, NSSB, and TIPS), and survival outcomes. Clinical characteristics of portal hypertension attributed to different etiologies, including hepatitis B, autoimmune liver disease, schistosomiasis, hematological disorders, and chemotherapy-induced liver injury, were compared. The efficacy and safety of endoscopic and interventional treatments for esophagogastric varices were evaluated. Factors influencing rebleeding rates among different treatment groups were analyzed, and reasons for inclusion in different groups were discussed.

Key facts

Study ID

NCT07358663

Run by

Shanghai Zhongshan Hospital

People needed

1384

Starts

2026-01-20

Expected to finish

2028-12-31

Last updated by the study team

2026-05-14

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Clinical diagnosis of portal hypertension with esophagogastric varices.
• Underwent abdominal CT and gastroscopy examinations.

You may not qualify if…

• Presence of peptic ulcer, gastric tumor, or other causes of gastrointestinal bleeding confirmed by imaging or gastroscopy.
• CT images of inadequate quality or incomplete medical history data.

Where it is running

• Zhongshan Hospital, Fudan University — Shanghai, China (enrolling)

Full record on ClinicalTrials.gov

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