Non-invasive Mapping-Guided Atrial Fibrillation Ablation
Recruiting now · Not applicable
Conditions studied: Atrial Fibrillation (AF)
In brief
The goal of this pilot study is to test if noninvasive global mapping can guide catheter ablation defining personalized targets and improve the therapy of atrial fibrillation. It will also test the safety of such an approach. The main questions it aims to answer are: * Does ablation of targets defined by noninvasive global mapping improve rates of acute atrial fibrillation termination? * Does such a personalized ablation approach reduce arrhythmia recurrence rates? Researchers will compare the results of the personalized ablation approach with comparable patients that had undergone a conventional "empirical" ablation approach (pulmonary vein isolation). Participants will: * Undergo a personalized catheter ablation approach employing both a noninvasive global mapping system and a conventional intracardiac mapping system * Visit the clinic 3, 6 and 12 months after ablation for clinical follow-up * Schedule a telephone visit 9 and 24 months after ablation for clinical follow-up
Key facts
- Study ID
- NCT07358611
- Run by
- Hospital Clinic of Barcelona
- People needed
- 30
- Starts
- 2026-01-31
- Expected to finish
- 2027-12-31
- Last updated by the study team
- 2026-07-08
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Ablation-naïve patients with:
- Persistent AF planned for catheter ablation plus
- Left atrial enlargement (LA diameter ≥45 mm or LA volume index ≥35ml/m2 or LA area ≥20 cm2)
You may not qualify if…
- Previous cardiac ablation
- Age <18 years
- Pregnancy or lactation
- Previous stroke/TIA
- Severe left ventricular dysfunction (LVEF <35%)
- Renal failure (GFR <30 ml/min)
- Dermal disease or hypersensitivity predisposing for skin irritation or exanthema
Where it is running
- Hospital Clinic, University of Barcelona — Barcelona, Spain (enrolling)
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.