Clinical Study on the Use of Huaier Granules for the Treatment of Proteinuria Related to Bevacizumab and Anlotinib in Lung Cancer Patients
Starting soon · Phase 4
Conditions studied: Proteinuria
In brief
This study is a prospective, multicenter, parallel-controlled clinical trial designed to evaluate the therapeutic efficacy of Huaier Granules for proteinuria occurring in lung cancer patients undergoing treatment with either Bevacizumab or Anlotinib.
Key facts
- Study ID
- NCT07358520
- Run by
- Fudan University
- People needed
- 40
- Starts
- 2026-01-28
- Expected to finish
- 2028-01-28
- Last updated by the study team
- 2026-01-22
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age ≥18 years;
- Histopathologically confirmed diagnosis of lung cancer;
- Receiving Bevacizumab or Anlotinib treatment;
- Positive urine protein detection, with 0.15g < 24-hour urinary protein quantification < 3.5g;
- No treatment with Huaier Granules within one month prior to enrollment;
- Expected survival time not less than 6 months;
- Voluntary participation in this study and provision of signed informed consent.
You may not qualify if…
- Known allergy, contraindication, or caution to any component of Huaier Granules;
- Inability to take oral medication;
- Required or ongoing use of drugs known to potentially affect proteinuria, including but not limited to ACE inhibitors, glucocorticoids (>3 weeks), and Chinese patent medicines (as per respective drug prescribing information);
- Proteinuria caused by underlying diseases, including but not limited to nephropathy, hypertension, urinary tract infection, systemic lupus erythematosus, multiple myeloma, etc.;
- Women who are pregnant, breastfeeding, or planning pregnancy;
- Currently participating in other clinical trials investigating drugs for treating proteinuria;
- Refusal to cooperate with follow-up;
- Any other reasons deemed by the investigator as unsuitable for participation in this study.
Where it is running
- Xuzhou Central Hospital — Xuzhou, Jiangsu, China
- Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine — Shanghai, Shanghai Municipality, China
Full record on ClinicalTrials.gov
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