Postoperative Outcomes of Single-stapled Anastomosis Combined With Transanal Natural Orifice Specimen Extraction
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Conditions studied: Rectal Cancer Patients, Rectal Cancer Surgery
In brief
Natural Orifice Specimen Extraction (NOSE) eliminates the need for additional abdominal incisions in minimally invasive colorectal procedures, potentially reducing the risk of wound complications and postoperative pain. In the context of restorative Total Mesorectal Excision (TME), single-stapling (SS) techniques facilitate NOSE through transanal rectal transection, as opposed to the conventional double-stapling technique. This study aims to explore the potential advantages of NOSE combined with SS anastomosis compared to conventional abdominal extraction in minimally invasive restorative TME.
Key facts
- Study ID
- NCT07358247
- Run by
- Istituto Clinico Humanitas
- People needed
- 190
- Starts
- 2026-01-31
- Expected to finish
- 2026-04-30
- Last updated by the study team
- 2026-01-22
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Adult patients aged more than 18 years old at the time of surgery
- Patients with a histological diagnosis of rectal adenocarcinoma
- Patients who underwent surgery between January 2017 and January 2023
- Patients with a low rectal tumor meeting the Low Rectal Cancer Development Programme (LOREC) criteria
You may not qualify if…
- Patients who underwent non-restorative procedures (including abdominoperineal resection or Hartmann's procedures).
- Patients who underwent immediate or delayed coloanal anastomosis.
- Patients who underwent open surgery.
- Patients who underwent unplanned conversion from minimally invasive to open approach.
- Patients with a concomitant diagnosis of Inflammatory Bowel Disease (IBD).
Where it is running
- IRCCS Humanitas Research Hospital — Rozzano, Milan, Italy
Full record on ClinicalTrials.gov
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