A Research Study to Compare Two Different Versions of Injectable CagriSema in People With Type 2 Diabetes
Withdrawn before enrolling · Phase 2 · Has a placebo group
Conditions studied: Diabetes Mellitus, Type 2
In brief
This study is being done to look at how well a study medicine called CagriSema helps people with diabetes lower their blood sugar. In this study the sponsor will compare two version of CagriSema injected by two different types of injection devices. Which treatment participants get is decided by chance. CagriSema is still being tested in studies and is not yet available for doctors to prescribe. The study will last for about 38 weeks.
Key facts
- Study ID
- NCT07357740
- Run by
- Novo Nordisk A/S
- People needed
- 0
- Starts
- 2026-08-27
- Expected to finish
- 2027-10-13
- Last updated by the study team
- 2026-07-09
Who can join
Age: 18 and older, up to 64. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Male or female (sex assigned at birth, inclusive of all gender identities).
- Age 18-64 years (both inclusive) at the time of signing the informed consent.
- Diagnosed with type 2 diabetes mellitus greater than or equal to (>=) 180 days before screening.
- Glycated haemoglobin (HbA1c) 7.0-10.5 percent (%) (53-91 [millimoles per mole] mmol/mol) (both inclusive) as determined by the central laboratory at screening.
- Stable daily dose >= 90 days before screening of metformin at effective or maximum tolerated dose as judged by the investigator.
- Body mass index (BMI) between 25.0 and 39.9 kilograms per square metre (kg/m\^2) (both inclusive) at screening. BMI will be calculated in the electronic case report form (eCRF) based on height and body weight at screening.
You may not qualify if…
- Renal impairment with estimated Glomerular Filtration Rate (eGFR) < 30 millilitre per minute per 1.73 square metre (mL/min/1.73 m\^2) as determined by the central laboratory at screening.
- Treatment with any anti-diabetic or anti-obesity medication (irrespective of indication) other than stated in the inclusion criteria within 90 days before screening.
- Uncontrolled and potentially unstable diabetic retinopathy or maculopathy. Verified by an eye examination performed within 90 days before screening or in the period between screening and randomisation.
- Previous exposure to CagriSema in a clinical study.
Where it is running
- Paradigm Clinical Research — San Diego, California, United States
- Encompass Clinical Research_Spring Valley — Spring Valley, California, United States
- Diablo Clinical Research, Inc. — Walnut Creek, California, United States
- Future Medical Research — Longwood, Florida, United States
- New Horizon Research Center — Miami, Florida, United States
- Clinical Site Partners Kendall Flourish Research — Miami, Florida, United States
- West Orange Endocrinology — Ocoee, Florida, United States
- Center for Diab,Obes & Metab — Pembroke Pines, Florida, United States
- American Research Centers of Florida — Pembroke Pines, Florida, United States
- Hope Clin Res & Wellness — Conyers, Georgia, United States
- Elevate Clinical Research — Gurnee, Illinois, United States
- Accellacare of Duly Oak Lawn — Oak Lawn, Illinois, United States
- KDCILM, LLC & Accellacare US, Inc. — Wilmington, North Carolina, United States
- Advanced Medical Research - Maumee — Maumee, Ohio, United States
- Clinical Res Collaborative — Cumberland, Rhode Island, United States
- Clinical Research Associates — Nashville, Tennessee, United States
- The Endocrine Center — Houston, Texas, United States
- Radiance Clinical Research — Lampasas, Texas, United States
- Quality Research Inc — San Antonio, Texas, United States
- Medrasa Clinical Research — Sherman, Texas, United States
- Sanos Clinic - Vejle — Vejle, Region Syddanmark, Denmark
- Sanos Clinic - Gandrup — Gandrup, Denmark
- Sanos Clinic - Herlev — Herlev, Denmark
- Regionshospitalet Viborg - Karkirurgisk Afsnit — Viborg, Denmark
- Arkansas Clinical Research — Little Rock, Arkansas, United States
Full record on ClinicalTrials.gov
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